byRothman, Abraham; Davidson, Stephanie; Wiencek, Robert G.; Evans, William N.; Restrepo, Humberto; Sarukhanov, Valeri; Ruoslahti, Erkki; Williams, Roy; Mann, David
This article is from Pulmonary Circulation , volume 3 . Abstract The molecular mechanisms of pulmonary arterial hypertension (PAH) remain ill-defined. The aims of this study were to obtain sequential endoarterial biopsy samples in a surgical porcine model of PAH and assess changes in histology and mRNA expression during the disease progression. Differentially expressed genes were then analyzed as potential pharmacological targets. Four Yucatan micro-pigs underwent surgical anastomosis of the... Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641740
byMalhotra, Rajeev; Hess, Dean; Lewis, Gregory D.; Bloch, Kenneth D.; Waxman, Aaron B.; Semigran, Marc J.
This article is from Pulmonary Circulation , volume 1 . Abstract Pulmonary vasodilator testing is currently used to guide management of patients with pulmonary arterial hypertension (PAH). However, the utility of the pulmonary vascular response to inhaled nitric oxide (NO) and oxygen in predicting survival has not been established. Eighty patients with WHO Group I PAH underwent vasodilator testing with inhaled NO (80 ppm with 90% O2 for 10 minutes) at the time of diagnosis. Changes in right... Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183738